Article

Prenatal sodium channel dysfunction in Dravet syndrome alters cortical development

2025-05-09

Abstract excerpt

<title>Abstract</title> <p>Neurodevelopmental disorders associated with epilepsy are typically linked to postnatal dysfunction of synaptic proteins and ion channels, yet increasing evidence suggests a role for these proteins before birth. The voltage-gated sodium channel Nav1.1, encoded by <italic>SCN1A</italic>, is well studied postnatally. <italic>SCN1A</italic> mutations result in a broad range of neurological...

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Literature Corpus work: 94e6a33e-f37a-5abb-b9d3-bf4715f7cdf4
DOI: 10.21203/rs.3.rs-6566247/v1

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