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The sodium channel SCN2A regulates cortical excitatory and inhibitory neurogenesis

2025-01-28

Abstract excerpt

Voltage-gated sodium channels regulate neuronal excitability and synaptic transmission in the postnatal and adult brain. The gene SCN2A , encoding the sodium channel Na v 1.2, regulates synaptic development and variants in SCN2A are associated with autism spectrum disorders (ASD) and a broad spectrum of epilepsy phenotypes, including early-onset developmental and epileptic encephalopathies. The expression patte...

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Literature Corpus work
fe6a734d-42d4-528d-b02f-af488e6a83f4
DOI
10.1101/2025.01.28.635170
Open publication

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