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Article

SCN1A mutations in Dravet syndrome: impact of interneuron dysfunction on neural networks and cognitive outcome.

Epilepsy & behavior : E&B - 1 Mar 2012

Bender Alex C, Morse Richard P, Scott Rod C, Holmes Gregory L, Lenck-Santini Pierre-Pascal

Abstract excerpt

Dravet syndrome (DS) is a childhood disorder associated with loss-of-function mutations in SCN1A and is characterized by frequent seizures and severe cognitive impairment. Animal studies have revealed new insights into the mechanisms by which mutations in this gene, encoding the type I voltage-gated sodium channel (Na(v)1.1), may lead to seizure activity and cognitive dysfunction. In this review, we further...

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Source

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Identifiers

PMID: 22341965
DOI: 10.1016/j.yebeh.2011.11.022
PMCID: PMC3307886

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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