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Article

Unraveling Dravet Syndrome: Exploring the complex effects of sodium channel mutations on neuronal networks.

Science progress - 1 Jan 2024

Doorn Nina

Abstract excerpt

Dravet Syndrome (DS) is a severe developmental epileptic encephalopathy with frequent intractable seizures accompanied by cognitive impairment, often caused by pathogenic variants in SCN1A encoding sodium channel NaV1.1. Recent research utilizing in vitro patient-derived neuronal networks and accompanying in silico models uncovered that not just sodium-but also potassium-and synaptic currents were impaired in DS...

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Share to Epilepsies, Myoclonic
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Share to NAV1.1 Voltage-Gated Sodium Channel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38373395
DOI: 10.1177/00368504231225076
PMCID: PMC10878221

Genes

SCN1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Unraveling Dravet Syndrome: Exploring the complex effects of sodium channel mutations on neuronal networks.PMID 38373395Read ↗

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