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Sexual dimorphism in epilepsy and comorbidities in Dravet syndrome mice carrying a targeted deletion of exon 1 of the <i>Scn1a</i> gene

2021-08-28

Abstract excerpt

<h4>Objective</h4> Dravet Syndrome (DS) is a catastrophic form of paediatric epilepsy associated with multiple comorbidities mainly caused by mutations in the SCN1A gene. DS progresses in three different phases termed febrile, worsening and stabilization stage. Mice that are haploinsufficient for Scn1a faithfully model each stage of DS, although various aspects have not been fully described, including the tempo...

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Literature Corpus work
86371a76-3b4f-5f3e-b065-bed7b6604172
DOI
10.1101/2021.08.27.457904
Open publication

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