Article

Developmental instability of CA1 pyramidal cells in Dravet Syndrome

2022-09-14

Abstract excerpt

Dravet Syndrome (DS) is mostly caused by heterozygous loss-of-function mutations in the voltage-gated sodium channel SCN1A (Na v 1.1), thought to result in severe epilepsy and neurodevelopmental impairment due to reduced interneuron excitability. Recent studies in mouse models suggest that an “interneuronopathy” alone does not completely explain all the cellular and network impairments seen in DS. Here, we inves...

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Literature Corpus work: e4dde729-c1ad-5241-b278-d5db1d8bd541
DOI: 10.1101/2022.09.12.507264

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