Back to search

Article

Developmentally-regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome

2021-07-28

Abstract excerpt

<h4>ABSTRACT</h4> Dravet syndrome (DS) is a neurodevelopmental disorder defined by epilepsy, intellectual disability, and sudden death, due to heterozygous variants in SCN1A with loss of function of the sodium channel subunit Nav1.1. Nav1.1-expressing parvalbumin GABAergic interneurons (PV-INs) from pre-weanling Scn1a+/− mice show impaired action potential generation. A novel approach assessing PV-IN function in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
63c47743-3499-5779-aba8-e21ed5b75524
DOI
10.1101/2021.07.28.454042
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Developmentally-regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndromeDOI 10.1101/2021.07.28.454042
Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndromeSemantic proximity
Parvalbumin interneuron impairment causes synaptic transmission deficits and seizures in SCN8A developmental and epileptic encephalopathySemantic proximity
A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet SyndromeSemantic proximity
Prenatal sodium channel dysfunction in Dravet syndrome alters cortical developmentSemantic proximity
Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development.Semantic proximity
Attenuated ectopic action potential firing in parvalbumin expressing interneurons in a mouse model of Dravet SyndromeSemantic proximity
Parvalbumin Interneuron Impairment Leads to Synaptic Transmission Deficits and Seizures in <i>SCN8A</i> Epileptic EncephalopathySemantic proximity
Loss of Grin2a causes a transient delay in the electrophysiological maturation of hippocampal parvalbumin interneuronsSemantic proximity
Axonopathy and altered synaptic development in early hippocampal epileptogenesis of Dravet syndromeSemantic proximity
Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndromeSemantic proximity
Loss of <i>Grin2a</i> Causes a Transient Delay in the Electrophysiological Maturation of Hippocampal Parvalbumin Interneurons: A Possible Mechanism for Transient Seizure Burden in Patients with Null <i>GRIN2A</i> VariantsSemantic proximity
Input-and cell-type-specific developmental alterations to thalamic synapses in a Dravet syndrome mouse modelSemantic proximity
Select a neighboring publication to make it the new centre.