Article
Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development.
Neurobiology of disease - 1 May 2015
Tsai Ming-Shian, Lee Meng-Larn, Chang Chun-Yun, Fan Hsiang-Hsuan, Yu I-Shing, Chen You-Tzung, You Jhih-Yi, Chen Chun-Yu, Chang Fang-Chia, Hsiao Jane H, Khorkova Olga, Liou Horng-Huei, Yanagawa Yuchio, Lee Li-Jen, Lin Shu-Wha
Abstract excerpt
Dravet syndrome (DS) is characterized by severe infant-onset myoclonic epilepsy along with delayed psychomotor development and heightened premature mortality. A primary monogenic cause is mutation of the SCN1A gene, which encodes the voltage-gated sodium channel subunit Nav1.1. The nature and timing of changes caused by SCN1A mutation in the hippocampal dentate gyrus (DG) network, a core area for gating major...
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