Article

Cell Painting predicts impact of lung cancer variants

2021-11-20

Abstract excerpt

Most variants in most genes across most organisms have an unknown impact on the function of the corresponding gene. This gap in knowledge is especially acute in cancer, where clinical sequencing of tumors now routinely reveals patient-specific variants whose functional impact on the corresponding gene is unknown, impeding clinical utility. Transcriptional profiling was able to systematically distinguish these vari...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f3d93f79-7e1f-5dc4-8314-27601a9271c0
DOI: 10.1101/2021.11.18.469171

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell Painting predicts impact of lung cancer variantsDOI 10.1101/2021.11.18.469171Read

Cell Painting predicts impact of lung cancer variants.Semantic proximity Read

Morphological map of under- and over-expression of genes in human cellsSemantic proximity Read

Massively parallel phenotyping of variant impact in cancer with Perturb-seq reveals a shift in the spectrum of cell states induced by somatic mutationsSemantic proximity Read

Advanced Cell Classifier: User-Friendly Machine-Learning-Based Software for Discovering Phenotypes in High-Content Imaging Data.Semantic proximity Read

Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effectsSemantic proximity Read

High-throughput Phenotyping of Lung Cancer Somatic Mutations.Semantic proximity Read

CanCellVar: A database for single-cell variants map in human cancer.Semantic proximity Read

Single-cell morphology encodes metastatic potential.Semantic proximity Read

Optimizing the Cell Painting assay for image-based profilingSemantic proximity Read

Massively parallel phenotyping of coding variants in cancer with Perturb-seq.Semantic proximity Read

Discovering chromatin dysregulation induced by protein-coding perturbations at scaleSemantic proximity Read

Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects.Semantic proximity Read