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Estimation of Neutral Mutation Rates and Quantification of Somatic Variant Selection Using cancereffectsizeR.

Cancer research - 15 Feb 2023

Mandell Jeffrey D, Cannataro Vincent L, Townsend Jeffrey P

Abstract excerpt

Somatic nucleotide mutations can contribute to cancer cell survival, proliferation, and pathogenesis. Although research has focused on identifying which mutations are "drivers" versus "passengers," quantifying the proliferative effects of specific variants within clinically relevant contexts could reveal novel aspects of cancer biology. To enable researchers to estimate these cancer effects, we developed...

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PMID: 36469362
DOI: 10.1158/0008-5472.CAN-22-1508
PMCID: PMC9929515

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