Article
High-throughput Phenotyping of Lung Cancer Somatic Mutations.
Cancer cell - 8 Aug 2016
Berger Alice H, Brooks Angela N, Wu Xiaoyun, Shrestha Yashaswi, Chouinard Candace, Piccioni Federica, Bagul Mukta, Kamburov Atanas, Imielinski Marcin, Hogstrom Larson, Zhu Cong, Yang Xiaoping, Pantel Sasha, Sakai Ryo, Watson Jacqueline, Kaplan Nathan, Campbell Joshua D, Singh Shantanu, Root David E, Narayan Rajiv, Natoli Ted, Lahr David L, Tirosh Itay, Tamayo Pablo, Getz Gad, Wong Bang, Doench John, Subramanian Aravind, Golub Todd R, Meyerson Matthew, Boehm Jesse S
Abstract excerpt
Recent genome sequencing efforts have identified millions of somatic mutations in cancer. However, the functional impact of most variants is poorly understood. Here we characterize 194 somatic mutations identified in primary lung adenocarcinomas. We present an expression-based variant-impact phenotyping (eVIP) method that uses gene expression changes to distinguish impactful from neutral somatic mutations. eVIP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.