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gAIRR-wgs: high-resolution T cell receptor allele typing in biobank-scale whole-genome sequencing data.

Briefings in bioinformatics - 3 Jul 2026

Huang Kuan-Ta, Yang Yu-Hsuan, Lin Mao-Jan, Lin Yu-Hui, Lai Sheng-Kai, Chou Ting-Hsuan, Lee Chieh-Yu, Hung Tsung-Kai, Hsu Chia-Lang, Yang Ya-Chien, Chen Chien-Yu, Chen Pei-Lung, Hsu Jacob Shu-Jui

Abstract excerpt

T cell receptor (TR) genes are essential components of the adaptive immune receptor repertoire, and growing evidence links TR germline variants to immune-related diseases. However, their highly allelic diversity and sequence homology make them challenging dark regions of the human genome. Current TR genotyping tools have limited support for population-scale studies using standard-depth (30×) whole-genome...

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PMID: 42617150
DOI: 10.1093/bib/bbag441
PMCID: PMC13489396

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