Article

Combined <i>MGMT</i> Expression and MMR Deficiency Underlie Poor Outcomes of Temozolomide in <i>IDH</i> -Wildtype Grade 2 Gliomas

2025-12-15

Abstract excerpt

<h4>Background</h4> Isocitrate dehydrogenase wildtype (IDHwt) histologic grade 2 adult diffuse gliomas represent a highly heterogeneous entity, and the effects of postoperative adjuvant temozolomide (TMZ) therapy, as well as the predictive value of chemotherapy-related biomarker O6-methylguanine-DNA methyltransferase promoter (MGMT-p) methylation, remain to be further investigated. <h4>Methods</h4> A Discovery d...

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Literature Corpus work: 9454556e-16e2-572b-8202-3be6d3e68a28
DOI: 10.64898/2025.12.12.25342173

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