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Molecular Characterization of IDH Wild-type Diffuse Astrocytomas: The Potential of cIMPACT-NOW Guidelines.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Jul 2022

Kumari Kalpana, Dandapath Iman, Singh Jyotsna, Rai Hitesh I S, Kaur Kavneet, Jha Prerana, Malik Nargis, Chosdol Kunzang, Mallick Supriya, Garg Ajay, Suri Ashish, Sharma Mehar C, Sarkar Chitra, Suri Vaishali

Abstract excerpt

IDH wild-type (wt) grade 2/3 astrocytomas are a heterogenous group of tumors with disparate clinical and molecular profiles. cIMPACT-NOW recommendations incorporated in the new 2021 World Health Organization (WHO) Classification of Central Nervous System (CNS) Tumors urge minimal molecular criteria to identify a subset that has an aggressive clinical course similar to IDH -wt glioblastomas (GBMs). This paper...

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PMID: 35708480
DOI: 10.1097/PAI.0000000000001038

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