Article
The comparison of clinical and biological characteristics between IDH1 and IDH2 mutations in gliomas.
Journal of experimental & clinical cancer research : CR - 31 May 2016
Wang Hao-Yuan, Tang Kai, Liang Ting-Yu, Zhang Wei-Zhong, Li Ji-Ye, Wang Wen, Hu Hui-Min, Li Ming-Yang, Wang Hui-Qing, He Xiao-Zheng, Zhu Zhi-Yuan, Liu Yan-Wei, Zhang Shi-Zhong
Abstract excerpt
BACKGROUND: Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are frequent in low-grade gliomas and secondary glioblastomas (sGBM). Because they yield the same oncometabolite, D-2-hydroxyglutarate, they are often treated as equivalent and pooled. The objective of this study was to provide insight into the differences between IDH1 and IDH2 mutant gliomas. METHODS: To investigate...
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