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Comparative Analysis of the Prognostic Significance of IDH,TERT, EGFR and MGMT Status in Patients with Adult Non-H3-Altered Grade 4 Gliomas: A Prospective Cohort Study.

World neurosurgery - 1 Jan 2024

Alimohamadi Maysam, Larijani Amirhossein, Pour-Rashidi Ahmad, Farzin Mostafa, Ebrahimi Hannan, Rahmani Mohamad, Hendi Kasra, Yarandi Kourosh Karimi, Aghajanian Sepehr, Shirani Mohammad

Abstract excerpt

INTRODUCTION: Gliomas continue to have a dismal prognosis. A myriad of genetic alterations has been described in this subset of tumors over the last decades. The integrative interpretation of the biomarker constellation for individual patients remains unclear. This study aims to evaluate the impact of some known genetic factors as prognostic biomarkers in grade 4 gliomas. METHODS: Adult non-H3-altered grade 4...

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PMID: 37914076
DOI: 10.1016/j.wneu.2023.10.102

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