Article

Astrocytic Synapse Engulfment Is Differentially Controlled by <i>APOE</i> Genotype

2026-05-06

Abstract excerpt

APOE gene variants encoding the apolipoprotein E (ApoE) protein are strong genetic modifiers of risk of Alzheimer’s disease (AD) with the APOE ε4 allele ( APOE4) associated with substantially increased disease risk, APOE ε2 allele ( APOE2 ) associated with decreased risk and APOE ε3 allele ( APOE3 ) considered neutral. Recently the Christchurch variant of APOE3 ( APOE3Ch ) has been shown to protect people...

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Literature Corpus work: 9424d7c9-0567-5588-8516-0e0a8ce8913d
DOI: 10.64898/2026.04.29.26351484

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