Article
Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes.
Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2016
Chung Won-Suk, Verghese Philip B, Chakraborty Chandrani, Joung Julia, Hyman Bradley T, Ulrich Jason D, Holtzman David M, Barres Ben A
Abstract excerpt
The strongest genetic risk factor influencing susceptibility to late-onset Alzheimer's disease (AD) is apolipoprotein E (APOE) genotype. APOE has three common isoforms in humans, E2, E3, and E4. The presence of two copies of the E4 allele increases risk by ∼12-fold whereas E2 allele is associated with an ∼twofold decreased risk for AD. These data put APOE central to AD pathophysiology, but it is not yet clear how...
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