Article

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

2019-10-07

Abstract excerpt

<h4>Summary</h4> Synapse loss correlates with cognitive decline in Alzheimer’s disease (AD). Data from mouse models suggests microglia are important for synapse degeneration, but direct human evidence for any glial involvement in synapse removal in human AD remains to be established. Here we observe astrocytes and microglia from human brains contain greater amounts of synaptic protein in AD compared to non-diseas...

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Literature Corpus work: 8c5d846a-903b-5782-86b4-3ea8bc42d4b7
DOI: 10.1101/795930

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