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Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice

11 Jan 2024

Abstract excerpt

Recent single-cell analyses have revealed the complexity of microglial heterogeneity in brain development, aging, and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Disease-associated microglia (DAMs) have been identified in ALS mice model, but their role in ALS pathology remains unclear. The effect of genetic background variations on microglial heterogeneity and functions remains...

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PMID: 38318390
DOI: 10.1016/j.isci.2024.108872

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