Article

Single-Cell Chromatin Accessibility Landscape of Human Umbilical Cord Blood in Trisomy 18 Syndrome

2021-04-26

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Trisomy 18 syndrome (Edwards syndrome, ES) is a type of aneuploidy caused by the presence of an extra chromosome 18. Aneuploidy is the leading cause of early pregnancy loss, intellectual disability, and multiple congenital anomalies.<bold>Results:</bold> In this study, we used the commercial Chromium platform (10x Genomics) to perform sc-ATAC-seq to measure chro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94046262-91ea-5a84-998f-7509532d6d05
DOI: 10.21203/rs.3.rs-327935/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Cell Chromatin Accessibility Landscape of Human Umbilical Cord Blood in Trisomy 18 SyndromeDOI 10.21203/rs.3.rs-327935/v1Read

A cell atlas of chromatin accessibility across 25 adult human tissuesSemantic proximity Read

A single-cell atlas of chromatin accessibility in the human genome.Semantic proximity Read

A multi-omics genome-and-transcriptome single-cell atlas of human preimplantation embryogenesis reveals the cellular and molecular impact of chromosome instabilitySemantic proximity Read

Single-cell transcriptomics reveals diverse and complex gene expression alterations in human trisomy 18Semantic proximity Read

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypesSemantic proximity Read

Single-cell multi-omics map of human foetal blood in Down’s SyndromeSemantic proximity Read

Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation FetusSemantic proximity Read

Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord BloodSemantic proximity Read

Single-cell epigenomics maps the continuous regulatory landscape of human hematopoietic differentiationSemantic proximity Read

Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart diseaseSemantic proximity Read

Single cell transcriptome in aneuploidies reveals mechanisms of gene dosage imbalanceSemantic proximity Read

Parallel Bimodal Single-cell Sequencing of Transcriptome and Chromatin AccessibilitySemantic proximity Read