Article

Single-cell transcriptomics reveals diverse and complex gene expression alterations in human trisomy 18

2019-12-03

Abstract excerpt

Trisomy 18, commonly known as Edward’s syndrome, is the second most common autosomal trisomy among live born neonates. Multiple tissues including cardiac, abdominal, and nervous systems are affected by an extra chromosome 18. To delineate the complexity of anomalies of trisomy 18, we analyzed amniotic fluid cells from two normal and three trisomy 18 samples using single-cell transcriptomics. We identified six cell...

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Literature Corpus work: a02f6404-2ef3-53c6-8005-867ce7d50d3d
DOI: 10.1101/863332

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