Article

Single-cell multi-omics map of human foetal blood in Down’s Syndrome

2023-09-27

Abstract excerpt

Down’s Syndrome (DS) predisposes individuals to haematological abnormalities, such as increased number of erythrocytes and leukaemia in a process that is initiated before birth and is not entirely understood. To understand dysregulated hematopoiesis in DS, we integrated single-cell transcriptomics of over 1.1 million cells with chromatin accessibility and spatial transcriptomics datasets using human foetal liver a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b3dea844-1b35-5fa8-a137-25e1b8d0e770
DOI: 10.1101/2023.09.25.559431

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell multi-omics map of human foetal blood in Down’s SyndromeDOI 10.1101/2023.09.25.559431Read

Single-cell multi-omics map of human fetal blood in Down syndrome.Semantic proximity Read

Identification of a DNA methylation signature in blood cells from persons with Down SyndromeSemantic proximity Read

The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesisSemantic proximity Read

Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndromeSemantic proximity Read

Mechanistic insights into Down syndrome comorbidities via convergent RNA-seq and TWAS signalsSemantic proximity Read

Low-pass whole genome bisulfite sequencing of neonatal dried blood spots identifies a role for RUNX1 in Down syndrome DNA methylation profilesSemantic proximity Read

Hematologic Neoplasms Associated with Down Syndrome: Cellular and Molecular Heterogeneity of the Diseases.Semantic proximity Read

Down syndrome-associated leukaemias: current evidence and challengesSemantic proximity Read

Low-Pass Whole Genome Bisulfite Sequencing of Neonatal Dried Blood Spots Identifies a Role for RUNX1 in Down Syndrome DNA Methylation ProfilesSemantic proximity Read

Hematologic Neoplasms Associated with Down Syndrome: Cellular and Molecular Heterogeneity of the Diseases.Semantic proximity Read

Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndromeSemantic proximity Read

Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia.Semantic proximity Read