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Article

alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.

Journal of neurochemistry - 1 Dec 2009

Jäger Sebastian, Leuchtenberger Stefanie, Martin Anne, Czirr Eva, Wesselowski Johanna, Dieckmann Marco, Waldron Elaine, Korth Carsten, Koo Edward H, Heneka Michael, Weggen Sascha, Pietrzik Claus U

Abstract excerpt

The Swedish mutation within the amyloid precursor protein (APP) causes early-onset Alzheimer's disease due to increased cleavage of APP by BACE1. While beta-secretase shedding of Swedish APP (APPswe) largely results from an activity localized in the late secretory pathway, cleavage of wild-type A...

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Source

Identifiers

PMID: 19804379
DOI: 10.1111/j.1471-4159.2009.06420.x

Genes

APP
BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19804379-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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