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Article

The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol.

Science (New York, N.Y.) - 1 Jun 2012

Barrett Paul J, Song Yuanli, Van Horn Wade D, Hustedt Eric J, Schafer Johanna M, Hadziselimovic Arina, Beel Andrew J, Sanders Charles R

Abstract excerpt

C99 is the transmembrane carboxyl-terminal domain of the amyloid precursor protein that is cleaved by γ-secretase to release the amyloid-β polypeptides, which are associated with Alzheimer's disease. Nuclear magnetic resonance and electron paramagnetic resonance spectroscopy show that the extracellular amino terminus of C99 includes a surface-embedded "N-helix" followed by a short "N-loop" connecting to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22654059
DOI: 10.1126/science.1219988
PMCID: PMC3528355

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