Article
The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.
Acta neuropathologica communications - 4 Nov 2015
Kokawa Asuka, Ishihara Seiko, Fujiwara Hitomi, Nobuhara Mika, Iwata Minori, Ihara Yasuo, Funamoto Satoru
Abstract excerpt
INTRODUCTION: The A673T mutation in the amyloid precursor protein (APP) protects against Alzheimer's disease by reducing β-amyloid protein (Aβ) production. This mutation reduced the release of the soluble APP fragment (sAPPβ), which is processed by β-secretase, suggesting a concomitant decrease in the β-carboxyl fragment of APP (C99), which is a direct substrate of γ-secretase for Aβ production. However, it...
Topics
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- CHO Cells
- Cell Fractionation
- Cholic Acids
- Cricetulus
- Green Fluorescent Proteins
- Immunoprecipitation
- Membrane Microdomains
- Mutation