Article

It takes two to tango: mast cell and Schwann cell interactions in neurofibromas

2003-12-15

Abstract excerpt

Neurofibromas are benign tumors comprised primarily of Schwann cells and fibroblasts. Mast cell infiltration is a well-known phenomenon; however, their role in tumor pathogenesis has been enigmatic. In an elegant set of experiments using cells derived from a murine model of neurofibromatosis 1 (NF1), Yang et al. dissect the molecular pathways involved in mast cell migration to neurofibromin-deficient Schwann cells...

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Literature Corpus work: 938bfe59-dae6-5ce9-8e65-96475865e5f0
DOI: 10.1172/jci200320503

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