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Article

Neurofibromas in NF1: Schwann cell origin and role of tumor environment.

Science (New York, N.Y.) - 3 May 2002

Zhu Yuan, Ghosh Pritam, Charnay Patrick, Burns Dennis K, Parada Luis F

Abstract excerpt

Neurofibromatosis type 1 (NF1) is one of the most prevalent dominantly inherited genetic diseases of the nervous system. NF1 encodes a tumor suppressor whose functional loss results in the development of benign neurofibromas that can progress to malignancy. Neurofibromas are complex tumors composed of axonal processes, Schwann cells, fibroblasts, perineurial cells, and mast cells. Through use of a conditional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11988578
DOI: 10.1126/science.1068452
PMCID: PMC3024710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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