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Article

Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling.

Human molecular genetics - 15 Aug 2006

Yang Feng-Chun, Chen Shi, Clegg Travis, Li Xiaohong, Morgan Trent, Estwick Selina A, Yuan Jin, Khalaf Waleed, Burgin Sarah, Travers Jeff, Parada Luis F, Ingram David A, Clapp D Wade

Abstract excerpt

Neurofibromas are common tumors found in neurofibromatosis type 1 (NF1) patients. These complex tumors are composed of Schwann cells, mast cells, fibroblasts and perineurial cells embedded in collagen that provide a lattice for tumor invasion. Genetic studies demonstrate that in neurofibromas, nullizygous loss of Nf1 in Schwann cells and haploinsufficiency of Nf1 in non-neuronal cells are required for...

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Identifiers

PMID: 16835260
DOI: 10.1093/hmg/ddl165
PMCID: PMC3024714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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