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Article

Mast cells and the neurofibroma microenvironment

16 Mar 2010

Abstract excerpt

Neurofibromatosis type 1 (NF1) is the most common genetic disorder with a predisposition to malignancy and affects 1 in 3500 persons worldwide. NF1 is caused by a mutation in the NF1 tumor suppressor gene that encodes the protein neurofibromin. Patients with NF1 have cutaneous, diffuse, and plexiform neurofibromas, tumors comprised primarily of Schwann cells, blood vessels, fibroblasts, and mast cells. Studies...

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Identifiers

PMID: 20233971
DOI: 10.1182/blood-2009-09-242875

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