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Article

The role of the immune system in neurofibromatosis type 1-associated nervous system tumors.

CNS oncology - 1 Jan 2017

Karmakar Souvik, Reilly Karlyne M

Abstract excerpt

With the recent development of new anticancer therapies targeting the immune system, it is important to understand which immune cell types and cytokines play critical roles in suppressing or promoting tumorigenesis. The role of mast cells in promoting neurofibroma growth in neurofibromatosis type 1 (NF1) patients was hypothesized decades ago. More recent experiments in mouse models have demonstrated the causal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28001089
DOI: 10.2217/cns-2016-0024
PMCID: PMC5514627

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