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Article

It takes two to tango: mast cell and Schwann cell interactions in neurofibromas.

The Journal of clinical investigation - 1 Dec 2003

Viskochil David H

Abstract excerpt

Neurofibromas are benign tumors comprised primarily of Schwann cells and fibroblasts. Mast cell infiltration is a well-known phenomenon; however, their role in tumor pathogenesis has been enigmatic. In an elegant set of experiments using cells derived from a murine model of neurofibromatosis 1 (NF1), Yang et al. dissect the molecular pathways involved in mast cell migration to neurofibromin-deficient Schwann...

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Identifiers

PMID: 14679174
DOI: 10.1172/JCI20503
PMCID: PMC297005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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