Pathogenesis of Plexiform Neurofibroma: Tumor-Stromal/Hematopoietic Interactions in Tumor Progression

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a genetic disease that results from either heritable or spontaneous autosomal dominant mutations in the NF1 gene. A second-hit mutation precedes the predominant NF1 neoplasms, which include myeloid leukemia, optic glioma, and plexiform neurofibroma. Despite this requisite NF1 loss of heterozygosity in the tumor cell of origin, nontumorigenic cells contribute to both generalized...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Meningioma and schwannoma management
• Share to Neurofibromatosis and Schwannoma Cases
• Share to Sarcoma Diagnosis and Treatment