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Article

Plexiform neurofibroma genesis: questions of Nf1 gene dose and hyperactive mast cells.

Current opinion in hematology - 1 Jul 2010

Staser Karl, Yang Feng-Chun, Clapp David W

Abstract excerpt

PURPOSE OF REVIEW: Tumorigenic cells can co-opt normal functions of nonmalignant hematopoietic cells, promoting tumor progression. Recent mouse and human studies indicate that mast cells underpin inflammation in the plexiform neurofibroma microenvironment of neurofibromatosis type 1. In this model, Nf1 homozygous-deficient Schwann cells recruit hyperactive mast cells, promoting tumorigenesis. Here, we discuss the...

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Identifiers

PMID: 20571392
DOI: 10.1097/MOH.0b013e328339511b
PMCID: PMC3539783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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