Article
Molecular, genetic, and cellular pathogenesis of neurofibromas and surgical implications.
Neurosurgery - 1 Jan 2006
Gottfried Oren N, Viskochil David H, Fults Daniel W, Couldwell William T
Abstract excerpt
Neurofibromatosis 1 (NF1) is a common autosomal dominant disease characterized by complex and multicellular neurofibroma tumors. Significant advances have been made in the research of the cellular, genetic, and molecular biology of NF1. The NF1 gene was identified by positional cloning. The functions of its protein product, neurofibromin, in RAS signaling and in other signal transduction pathways are being...
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