Article
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.
The Journal of clinical investigation - 1 Dec 2003
Yang Feng-Chun, Ingram David A, Chen Shi, Hingtgen Cynthia M, Ratner Nancy, Monk Kelly R, Clegg Travis, White Hilary, Mead Laura, Wenning Mary Jo, Williams David A, Kapur Reuben, Atkinson Simon J, Clapp D Wade
Abstract excerpt
The NF1 tumor suppressor gene encodes a GTPase-activating protein called neurofibromin that negatively regulates Ras signaling. Mutations in NF1 cause neurofibromatosis type 1 (NF1). The development of neurofibromas, which are complex tumors composed of multiple cell types, is a hallmark of NF1. Somatic inactivation of murine Nf1 in Schwann cells is necessary, but not sufficient, to initiate neurofibroma...
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