Article

Bruton's tyrosine kinase control of cytokine production in Toll-like receptor signalling

2011-01-01

Abstract excerpt

Inappropriate and un-regulated inflammation is the hallmark of a variety of inflammatory diseases including Rheumatoid Arthritis (RA). Central to the pathogenesis of this disease is the cytokine Tumour Necrosis Factor α (TNF), a product of activated macrophages. Macrophages are activated by numerous exogenous and endogenous ligands through Toll like receptors (TLR) leading to the activation of numerous protein tyr...

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Literature Corpus work: 93784b78-a231-5654-897e-9c820b055f40
DOI: 10.25560/7094

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