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Article

Btk is a positive regulator in the TREM-1/DAP12 signaling pathway

10 Jun 2011

Abstract excerpt

The triggering receptor expressed on myeloid cells 1 (TREM-1) has been implicated in the production of proinflammatory cytokines and chemokines during bacterial infection and sepsis. For downstream signal transduction, TREM-1 is coupled to the ITAM-containing adaptor DAP12. Here, we demonstrate that Bruton tyrosine kinase (Btk), a member of the Tec kinases, becomes phosphorylated upon TREM-1 triggering. In...

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Identifiers

PMID: 21659545
DOI: 10.1182/blood-2010-11-317016

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