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Article

The role of Bruton’s tyrosine kinase in autoimmunity and implications for therapy

11 Feb 2016

Abstract excerpt

Bruton's tyrosine kinase (BTK) mediates B cell signaling and is also present in innate immune cells but not T cells. BTK propagates B cell receptor (BCR) responses to antigen-engagement as well as to stimulation via CD40, toll-like receptors (TLRs), Fc receptors (FCRs) and chemokine receptors. Importantly, BTK can modulate signaling, acting as a "rheostat" rather than an "on-off" switch; thus, overexpression...

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PMID: 26864273
DOI: 10.1586/1744666x.2016.1152888

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