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Article

Signalling of Bruton's Tyrosine Kinase, Btk

1 Feb 1999

Abstract excerpt

Bruton's tyrosine kinase, which is encoded by the BTK gene, is a cytoplasmic protein tyrosine kinase (PTK) crucial for B-cell development and differentiation. It belongs to the Tec family of PTKs containing several domains that are characteristic of signalling molecules. In humans, mutations that disrupt the function of this gene lead to the classical XLA syndrome (X-linked agammaglobulinaemia), a primary...

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Identifiers

PMID: 10075013
DOI: 10.1046/j.1365-3083.1999.00504.x

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