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Article

Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells.

Neurochemistry international - 1 Jul 2021

Nazish Iqra, Arber Charles, Piers Thomas M, Warner Thomas T, Hardy John A, Lewis Patrick A, Pocock Jennifer M, Bandopadhyay Rina

Abstract excerpt

LRRK2 protein is expressed prominently in immune cells, cell types whose contribution to LRRK2-associated genetic Parkinson's disease (PD) is increasingly being recognised. We investigated the effect of inflammatory stimuli using RAW264.7 murine macrophage cells as model systems. A detailed time course of TLR2 and TLR4 stimulation was investigated through measuring LRRK2 phosphorylation at its specific...

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Identifiers

PMID: 34004238
DOI: 10.1016/j.neuint.2021.105070
PMCID: PMC7610942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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