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Article

Amplification of IL-21 signalling pathway through Bruton’s tyrosine kinase in human B cell activation

26 Feb 2015

Abstract excerpt

OBJECTIVE: B cells play an important role in the pathogenesis of autoimmune diseases. The role of Bruton's tyrosine kinase (Btk) in cytokine-induced human B cell differentiation and class-switch recombination remains incompletely defined. This study analysed the effect of Btk on human activated B cells. METHODS: Purified B cells from healthy subjects were stimulated with B cell receptor (BCR) and other stimuli...

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PMID: 25724205
DOI: 10.1093/rheumatology/keu532

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