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Article

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

The Journal of biological chemistry - 11 Jul 2003

Jefferies Caroline A, Doyle Sarah, Brunner Cornelia, Dunne Aisling, Brint Elizabeth, Wietek Claudia, Walch Eva, Wirth Thomas, O'Neill Luke A J

Abstract excerpt

In this study we have identified members of the Toll-like receptor (TLR) family (namely, TLRs 4, 6, 8, and 9) as proteins to which the intracellular protein tyrosine kinase, Bruton's tyrosine kinase (Btk), binds. Detailed analysis of the interaction between Btk and TLR8 demonstrates that the pres...

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Source

Identifiers

PMID: 12724322
DOI: 10.1074/jbc.M301484200

Genes

TLR4
TLR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12724322-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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