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Article

Bruton tyrosine kinase mediates TLR9-dependent human dendritic cell activation.

The Journal of allergy and clinical immunology - 1 Jun 2014

Lougaris Vassilios, Baronio Manuela, Vitali Massimiliano, Tampella Giacomo, Cattalini Marco, Tassone Laura, Soresina Annarosa, Badolato Raffaele, Plebani Alessandro

Abstract excerpt

BACKGROUND: Bruton tyrosine kinase (BTK) plays an essential role in various biologic functions of different cell types. Mutations in BTK lead to X-linked agammaglobulinemia (XLA) in humans. BTK was recently linked to the innate immune system, in particular, the Toll-like receptor (TLR) pathway; however, the TLR9 pathway has never been studied in dendritic cells (DCs) of patients with XLA. OBJECTIVE: The aim of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24612681
DOI: 10.1016/j.jaci.2013.12.1085

Genes

BTK
TLR9
STAT1
TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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