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Article

LINE-1 retrotransposition is a recurrent cause of <i>MET</i> exon 14 skipping in cancer

2026-02-20

Abstract excerpt

<h4>ABSTRACT</h4> MET exon 14 skipping is a pathogenic event that results in decreased ubiquitin-mediated degradation of the MET receptor, sustained oncogenic signaling, and conferred sensitivity to MET tyrosine kinase inhibitors. While exon 14 skipping is most commonly caused by somatically acquired base substitutions and small indels near the exon 14 splice sites, here we report nine cases in which long intersp...

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Identifiers and source

Literature Corpus work
9376ed78-8ddc-52e9-a48e-406836a7be67
DOI
10.64898/2026.02.19.706876
Open publication

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LINE-1 retrotransposition is a recurrent cause of <i>MET</i> exon 14 skipping in cancerDOI 10.64898/2026.02.19.706876
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