Article

Atf3 controls transitioning in female mitochondrial cardiomyopathy as identified by single-cell transcriptomics

2023-09-11

Abstract excerpt

<h4>Summary</h4> Oxidative phosphorylation defects results in mitochondrial diseases, with cardiac involvement markedly impacting prognosis. However, the mechanisms underlying the transition from compensation to dysfunction in response to metabolic deficiency remain unclear, impeding the development of effective treatments. Here, we employed single-nucleus RNA sequencing (snRNA-seq) on hearts from mitochondrial c...

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Literature Corpus work: 935cf625-e8eb-5d67-9a5d-16876ad790a3
DOI: 10.1101/2023.09.11.557118

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