Deciphering human heart failure with preserved ejection fraction (HFpEF) at single cell resolution

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Heart failure with preserved ejection fraction (HFpEF) is a complex and growing condition, representing over half of all heart failure cases. Despite its high morbidity and mortality, its heterogeneity and limited therapeutic options pose significant challenges. Understanding the molecular mechanisms driving HFpEF is essential for the development of new therapies to improve...

Topics

Open a Topic to create a Post that cites this publication.

• Atherosclerosis and Cardiovascular Diseases
• Cardiac Fibrosis and Remodeling
• Cardiovascular Function and Risk Factors
• Congenital heart defects research
• IL-33, ST2, and ILC Pathways
• Signaling Pathways in Disease
• Single-cell and spatial transcriptomics
• Viral Infections and Immunology Research

Identifiers and source

Literature Corpus work

1ca25d6f-63a1-50d0-b76c-a2ca1078326e

DOI

10.1101/2025.04.02.646923