Article

Single cell transcriptomic analyses of human heart failure with preserved ejection fraction

2025-03-12

Abstract excerpt

<h4>Background: </h4> Heart failure with preserved ejection fraction (HFpEF) is a poorly understood, multi-system disease with high morbidity and mortality. To improve our understanding of its underlying biology, we used single-nucleus RNA sequencing (snRNA-seq) to characterize cell-specific gene expression patterns in human HFpEF myocardium. <h4>Methods:</h4> Septal myocardial biopsies (2-3 mg) from 30 HFpEF pati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ca06ffc3-8f0d-5098-b3c7-9c3b8a1a125d
DOI: 10.1101/2025.03.06.641949

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell transcriptomic analyses of human heart failure with preserved ejection fractionDOI 10.1101/2025.03.06.641949Read

Deciphering human heart failure with preserved ejection fraction (HFpEF) at single cell resolutionSemantic proximity Read

Pathogenic variants damage cell composition and single cell transcription in cardiomyopathiesSemantic proximity Read

Single-cell transcriptomics reveals cell-type-specific diversification in human heart failureSemantic proximity Read

Single Cell Transcriptomics Reveals Cell Type Specific Diversification in Human Heart FailureSemantic proximity Read

Transcriptional and Cellular Diversity of the Human HeartSemantic proximity Read

HeartMap: An Integrated Cell Atlas of 2.4 million cells across 209 Individuals in Health and DiseaseSemantic proximity Read

A Method for Cryopreservation and Single Nucleus RNA-sequencing of Normal Adult Human Interventricular Septum Heart Tissue Reveals Cellular Diversity and FunctionSemantic proximity Read

Chamber-enriched gene expression profiles in failing human hearts with reduced ejection fractionSemantic proximity Read

Spatial transcriptional landscape of human heart failureSemantic proximity Read

From Cell to Gene: Deciphering the Mechanism of Heart Failure With Single‐Cell SequencingSemantic proximity Read

Advancing Nuclei Isolation from Frozen Human Heart for Single-Nucleus RNA Sequencing ApplicationsSemantic proximity Read

Transcriptional Atlas of Cardiac DiseaseSemantic proximity Read