Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Understanding of the characteristics of fibroblasts in ischemic cardiomyopathy using single-nucleus RNA sequencing

29 May 2025

Abstract excerpt

Fibroblasts play a crucial role in the development and progression of heart failure in many heart-related diseases. However, the contributions of fibroblast and its subtypes to the pathogenesis of ischemic cardiomyopathy (ICM) remain unclear. In this study, we analyzed single-nucleus RNA sequencing data from cardiac tissues of seven ICM patients with heart failure and eight control subjects. Our findings indicate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy and Myosin Studies
Share to Cardiovascular Function and Risk Factors
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40447667
DOI: 10.1038/s41598-025-00260-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Understanding of the characteristics of fibroblasts in ischemic cardiomyopathy using single-nucleus RNA sequencingPMID 40447667Read ↗

Understanding of the characteristics of fibroblasts in ischemic cardiomyopathy using single- nucleus RNA sequencingSemantic proximity Read ↗

Integrative Single-Cell Analysis of Cardiomyopathy Identifies Differences in Cell Stemness and Transcriptional Regulatory Networks among Fibroblast SubpopulationsSemantic proximity Read ↗

Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathySemantic proximity Read ↗

Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathySemantic proximity Read ↗

Transcriptional Atlas of Cardiac DiseaseSemantic proximity Read ↗

Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levelsSemantic proximity Read ↗

Location and aetiology are determinants of fibroblast activation and heterogeneity in the failing human heartSemantic proximity Read ↗

Characterising Shared and Specific Cell–Cell Communication in Cardiomyopathy Subtypes From Single‐Cell Transcriptomics DataSemantic proximity Read ↗

Integration mapping of cardiac fibroblast single-cell transcriptomes elucidates cellular principles of fibrosis in diverse pathologiesSemantic proximity Read ↗

HeartMap: An Integrated Cell Atlas of 2.4 million cells across 209 Individuals in Health and DiseaseSemantic proximity Read ↗

Deciphering human heart failure with preserved ejection fraction (HFpEF) at single cell resolutionSemantic proximity Read ↗

Deciphering Cell-Type-Specific Gene Expression Signatures of Cardiac Diseases Through Reconstruction of Bulk TranscriptomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.