Back to search

Article

Understanding of the characteristics of fibroblasts in ischemic cardiomyopathy using single- nucleus RNA sequencing

2025-04-03

Abstract excerpt

<title>Abstract</title> <p>Fibroblasts play a crucial role in the development and progression of heart failure in many heart-related diseases. However, the contributions of fibroblast and its subtypes to the pathogenesis of ischemic cardiomyopathy (ICM) remain unclear. In this study, we analyzed single-nucleus RNA sequencing data from cardiac tissues of seven ICM patients with heart failure and eight control subj...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
695c9eda-5890-52a9-a679-7cc580df1b97
DOI
10.21203/rs.3.rs-5552693/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Understanding of the characteristics of fibroblasts in ischemic cardiomyopathy using single- nucleus RNA sequencingDOI 10.21203/rs.3.rs-5552693/v1
Understanding of the characteristics of fibroblasts in ischemic cardiomyopathy using single-nucleus RNA sequencingSemantic proximity
Transcriptional Atlas of Cardiac DiseaseSemantic proximity
Integrative Single-Cell Analysis of Cardiomyopathy Identifies Differences in Cell Stemness and Transcriptional Regulatory Networks among Fibroblast SubpopulationsSemantic proximity
Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathySemantic proximity
Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levelsSemantic proximity
Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathySemantic proximity
Deciphering human heart failure with preserved ejection fraction (HFpEF) at single cell resolutionSemantic proximity
Location and aetiology are determinants of fibroblast activation and heterogeneity in the failing human heartSemantic proximity
SnRNA-seq reveals differential functional transcriptional pathway alterations in three mutant types of dilated cardiomyopathy.Semantic proximity
Characterising Shared and Specific Cell–Cell Communication in Cardiomyopathy Subtypes From Single‐Cell Transcriptomics DataSemantic proximity
Integration mapping of cardiac fibroblast single-cell transcriptomes elucidates cellular principles of fibrosis in diverse pathologiesSemantic proximity
HeartMap: An Integrated Cell Atlas of 2.4 million cells across 209 Individuals in Health and DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.